Problem 1.1.1 – Construct chemokine signalling pathway (22 points)
Based on Appendix 1 sentences, add edges between nodes. Click a node, then another, choose type & state. Click on an edge to delete it. Submit to see your score.
💡 Instructions: Click a node (highlighted), then click another node → choose interaction type (Activation/Inhibition/Dissociation) and state (Direct/Indirect). Click on an edge line to delete it. Drag nodes to rearrange. Submit to check against official answer key.
Chemokine Signalling Pathway (KEGG view)
Gene expression & FC simulation (Q1.2.4, Q1.3.1, Q1.4.2–1.4.4)
Gene
Control expr
Case expr
FC (calculated)
Editable FC (for simulation)
PSF status: Not calculated yet. Click "Calculate PSF" to see signal values.
Q1.2.1 (8 points) – True/False
Q1.2.2 (8 points) – True/False
Q1.2.3 (8 points) – True/False
Q1.3.2 (2 points) – Which gene(s) have FC ≥ 2?
Q1.4.1 (4 points) – Which process is suppressed?
Q1.4.2 (4 points) – Gene whose mutation has least consequence
Q1.4.3 (4 points) – Effect of Compound A (Akt inhibitor)
Q1.4.4 (8 points) – Best compound to restore suppressed process