Q37 - Restriction Fragment Analysis of a Growth Hormone Deletion
DNA from five members of a family, in which dwarf growth occurs (Fig. A), was examined using restriction enzymes, DNA probes, and gel electrophoresis (Fig. B). Dwarf growth occurs due to deficiency of growth hormone. A, pedigree with a dwarf member (2); B, gel electrophoresis plate with size of fragments to the left. DNA from a control person (ctrl) without this type of mutation was also examined.
Figure 1.
Using the information and data, determine which of the statements are true or which are false.
A. The gene for growth hormone is situated within the 26 kb DNA sequence
B. The mutation is due to a deletion of the size of 26 kb
C. III-4 will most probably not have children that lack growth hormone
D. The risk that a fourth child of II-1 and II-5 will be a dwarf is 50%
Question reproduced from IBO 2015, Theoretical Exam A, licensed under CC BY-NC-SA 4.0 - attributed to the International Biology Olympiad. Open the full exam PDF · Community solutions (unofficial)