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Q8 - Identifying Amino Acids from Peptide Mass Data

Theoretical A Real exam question - full text reproduced under IBO's CC BY-NC-SA 4.0 license

A scientist has isolated five different peptides (1 to 5) containing five amino acids (named A, B, C, D, E). He determined the mass and the sequence of each peptide. The data which he obtained is shown on the table below.

Peptide Amino Acids Sequence Mass (Da)
1 BCDACCDEDCB 966
2 ABBCAEEDECB 1099
3 BACDAEAEECA 1357
4 CACADBACAEB 1279
5 EDDCABBCCEE 1014

The mass of individual amino acids are shown in the table below (in Da; note: the mass of a water molecule is 18 Da, subtracted once per peptide bond during formation).

Amino acid Mass (Da) Amino acid Mass (Da)
Alanine 89 Leucine 131
Arginine 174 Lysine 146
Asparagine 132 Methionine 149
Aspartic Acid 133 Phenylalanine 165
Cysteine 121 Proline 115
Glutamic Acid 147 Serine 105
Glutamine 146 Threonine 119
Glycine 75 Tryptophan 204
Histidine 155 Tyrosine 181
Isoleucine 131 Valine 117

Using the information and data, determine which of the statements are true or which are false.

A. Amino acid named C is serine
B. Amino acid named A is tyrosine
C. Amino acid named E is cysteine
D. Amino acid named B is glycine

Question reproduced from IBO 2016, Theoretical Paper A, licensed under CC BY-NC-SA 4.0 - attributed to the International Biology Olympiad. Open the full exam PDF · Community solutions (unofficial)