Q37 - Rerouting Flux Through an Engineered Krebs Cycle for Lysine
Sir Hans Krebs (1900-1981) uncovered the major biochemical pathway of mitochondria. The Krebs cycle was artificially modified in a free prokaryote to maximise lysine production.
Using the information and data, determine which of the statements are true or which are false.
A. Blocking the final step of threonine synthesis leads to an unregulated increase in lysine synthesis.
B. Increasing ID activity increases lysine synthesis.
C. Making PEPC insensitive to malate/aspartate increases lysine synthesis.
D. Increasing PEPCK activity increases lysine synthesis.
Question reproduced from IBO 2017, Theoretical Exam B, licensed under CC BY-NC-SA 4.0 - attributed to the International Biology Olympiad. Open the full exam PDF · Official answer key & worked solutions