Q11 - Kartagener Syndrome
Kartagener syndrome, a rare disease, is caused by loss-of-function mutations in the molecular complex shown in the image indicated by the blue arrows. (Note: the figure shows wild type). The syndrome has multiple symptoms, all with one molecular mechanism in common.
True or false?
Q11.1. Due to the impairment of fluid currents in embryonal development, affected individuals can exhibit disturbance in the determination of the right-left symmetry of internal organs.
Q11.2. Symptoms include disturbance of the movement of digestive material in the gastrointestinal tract.
Q11.3. Symptoms include reduced mucus clearance from the lungs leading to chronic recurrent respiratory infections.
Q11.4. Symptoms include reduction in fertility in females due to immobility of the oocyte/early embryo in the fallopian tube.
Q11.5. Couples where the males have this condition often need In-vitro fertilization (IVF) assistance to conceive.
Question reproduced from IBO 2023, Theoretical Paper 2, licensed under CC BY-NC-SA 4.0 - attributed to the International Biology Olympiad. Open the full exam PDF