Q27 - Arouser Links Egfr Signalling to Alcohol Sensitivity and Social Isolation
The most important signalling pathways of development and cancer were discovered by epistasis analyses in fruit-flies (Drosophila melanogaster). Such screens also showed the protein encoded by the Arouser gene mediates signals along the Epidermal growth factor receptor (Egfr) pathway in neurons. Arouser knockout flies are unusually sensitive to ethanol (get drunk easily).
Using the information and data, determine which of the statements are true or which are false.
A. Wild type Arouser facilitates alcohol tolerance.
B. Blocking Egfr activity increases alcohol sensitivity.
C. Over-expression of Akt in arouser knockout flies increases alcohol sensitivity.
D. Socially isolating arouser knockouts makes them more like WT flies.
Question reproduced from IBO 2017, Theoretical Exam A, licensed under CC BY-NC-SA 4.0 - attributed to the International Biology Olympiad. Open the full exam PDF · Official answer key & worked solutions